Showing posts with label Childhood. Show all posts
Showing posts with label Childhood. Show all posts

Friday, 12 July 2013

Study Evaluates The Impact Of Childhood Temperament On Later Alcohol Use/Problems

Main Category: Alcohol / Addiction / Illegal Drugs
Also Included In: Pediatrics / Children's Health;  Psychology / Psychiatry
Article Date: 12 Jul 2013 - 1:00 PDT Current ratings for:
Study Evaluates The Impact Of Childhood Temperament On Later Alcohol Use/Problems
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Most risk and protective factors for alcohol use have roots in early childhood. In other words, an individual enters adolescence with personality characteristics and life experiences that have accumulated during the first decade of life. An evaluation of measures of temperament from children six months through to five years of age has found that childhood temperament prior to age five predicts adolescent alcohol use and problems at age 15.5 years, even after controlling for socio-demographic factors and parental alcohol problems.

Results will be published in the December 2013 issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View.

"Most scientists who study alcohol use start studying people in adolescence, since that is when alcohol use is usually first initiated/experimented with," explained Danielle Dick, associate professor of psychiatry, psychology and human and molecular genetics with the Virginia Institute for Psychiatric and Behavioral Genetics at Virginia Commonwealth University, as well as corresponding author for the study. "But people don't enter adolescence as blank slates; they have a history of life experiences that they bring with them, dating back to early childhood. This is one of the most comprehensive attempts to understand very early childhood predictors of adolescent alcohol use in a large epidemiological cohort."

"A question largely unanswered by the existing literature concerns the origins of personality differences in adolescents or adults who do and do not have drinking problems," added Matt McGue, Regents Professor in the department of psychology at the University of Minnesota. "In my opinion, the major contribution of the current study is that it shows that these personality differences emerge very early in life."

Dick and her colleagues used data from the Avon Longitudinal Study of Parents and Children (ALSPAC), a large epidemiological sample of pregnant women with delivery dates between April 1991 and December 1992. The children (6,504 boys, 6,143 girls) were followed longitudinally. Temperamental characteristics were assessed at six time points from six to 69 months of age. Alcohol use and problems were assessed at age 15.5 years.

"Some of the most interesting findings to emerge from this study are that, one, we can identify childhood temperamental styles that emerge prior to age five that predict alcohol use and problems in mid-adolescence," said Dick. "Two, the early childhood temperamental styles that predict alcohol use are very different and largely uncorrelated - that both kids who show consistent emotional and behavioral problems early on are at elevated risk and kids who are consistently sociable at a very early age are also at risk. This indicates very different pathways to alcohol involvement/patterns, that emerge early on, which has important implications for prevention efforts."

"Temperament is considered to represent the biological foundations of later personality and is manifested in terms of basic reactivity and regulatory process," said McGue. "This study differs from other studies in two significant ways. First, other studies have typically focused on personality, which is normally assessed by self-report. This study indicates that those personality factors are the result, in part, of early temperamental expressions. Second, ALSPAC is a large and very well characterized longitudinal study. This allows the investigators to rigorously evaluate their hypothesis as well as provide them with the statistical power they need to explore important ancillary questions, such as whether the nature of personality risk differs in males and females, a gender effect they did not find in this study."

"Interestingly, the association between sociability and alcohol use/problems was more significant than the association found between emotional and conduct difficulties and later alcohol problems, said Dick. "This underscores the fact that drinking during adolescence is largely a social phenomenon. However, this doesn't mean it's less problematic; we know from other studies that most adolescent drinking is high risk - for example, binge drinking - and can lead to numerous negative consequences."

Both Dick and McGue noted the importance of searching for what may lead to adolescent drinking when trying to understand the development of patterns of alcohol use, such as predictors that emerge very early in life.

"That said," noted McGue, "while I think the most important finding concerns tracing personality differences back to preschool differences in temperament, we cannot, from these findings, predict with much accuracy which preschoolers will have problems with alcohol as adolescents and which will not." McGue spoke favorably of unrelated Canadian research that targets personality risk factors for substance abuse; rather than trying to change the personalities of adolescents, scientists are attempting to teach them how to deal with their personalities.

"All things considered," said Dick, "it's not just 'problem kids' who get involved in alcohol use. It's also the highly sociable kids as well. Parents should be aware of this."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our alcohol / addiction / illegal drugs section for the latest news on this subject. Please use one of the following formats to cite this article in your essay, paper or report:

MLA

University, Virginia Commonwealth. "Study Evaluates The Impact Of Childhood Temperament On Later Alcohol Use/Problems." Medical News Today. MediLexicon, Intl., 12 Jul. 2013. Web.
12 Jul. 2013. APA

Please note: If no author information is provided, the source is cited instead.


'Study Evaluates The Impact Of Childhood Temperament On Later Alcohol Use/Problems'

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View the original article here

Study Evaluates The Impact Of Childhood Temperament On Later Alcohol Use/Problems

Main Category: Alcohol / Addiction / Illegal Drugs
Also Included In: Pediatrics / Children's Health;  Psychology / Psychiatry
Article Date: 12 Jul 2013 - 1:00 PDT Current ratings for:
Study Evaluates The Impact Of Childhood Temperament On Later Alcohol Use/Problems
not yet ratednot yet rated

Most risk and protective factors for alcohol use have roots in early childhood. In other words, an individual enters adolescence with personality characteristics and life experiences that have accumulated during the first decade of life. An evaluation of measures of temperament from children six months through to five years of age has found that childhood temperament prior to age five predicts adolescent alcohol use and problems at age 15.5 years, even after controlling for socio-demographic factors and parental alcohol problems.

Results will be published in the December 2013 issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View.

"Most scientists who study alcohol use start studying people in adolescence, since that is when alcohol use is usually first initiated/experimented with," explained Danielle Dick, associate professor of psychiatry, psychology and human and molecular genetics with the Virginia Institute for Psychiatric and Behavioral Genetics at Virginia Commonwealth University, as well as corresponding author for the study. "But people don't enter adolescence as blank slates; they have a history of life experiences that they bring with them, dating back to early childhood. This is one of the most comprehensive attempts to understand very early childhood predictors of adolescent alcohol use in a large epidemiological cohort."

"A question largely unanswered by the existing literature concerns the origins of personality differences in adolescents or adults who do and do not have drinking problems," added Matt McGue, Regents Professor in the department of psychology at the University of Minnesota. "In my opinion, the major contribution of the current study is that it shows that these personality differences emerge very early in life."

Dick and her colleagues used data from the Avon Longitudinal Study of Parents and Children (ALSPAC), a large epidemiological sample of pregnant women with delivery dates between April 1991 and December 1992. The children (6,504 boys, 6,143 girls) were followed longitudinally. Temperamental characteristics were assessed at six time points from six to 69 months of age. Alcohol use and problems were assessed at age 15.5 years.

"Some of the most interesting findings to emerge from this study are that, one, we can identify childhood temperamental styles that emerge prior to age five that predict alcohol use and problems in mid-adolescence," said Dick. "Two, the early childhood temperamental styles that predict alcohol use are very different and largely uncorrelated - that both kids who show consistent emotional and behavioral problems early on are at elevated risk and kids who are consistently sociable at a very early age are also at risk. This indicates very different pathways to alcohol involvement/patterns, that emerge early on, which has important implications for prevention efforts."

"Temperament is considered to represent the biological foundations of later personality and is manifested in terms of basic reactivity and regulatory process," said McGue. "This study differs from other studies in two significant ways. First, other studies have typically focused on personality, which is normally assessed by self-report. This study indicates that those personality factors are the result, in part, of early temperamental expressions. Second, ALSPAC is a large and very well characterized longitudinal study. This allows the investigators to rigorously evaluate their hypothesis as well as provide them with the statistical power they need to explore important ancillary questions, such as whether the nature of personality risk differs in males and females, a gender effect they did not find in this study."

"Interestingly, the association between sociability and alcohol use/problems was more significant than the association found between emotional and conduct difficulties and later alcohol problems, said Dick. "This underscores the fact that drinking during adolescence is largely a social phenomenon. However, this doesn't mean it's less problematic; we know from other studies that most adolescent drinking is high risk - for example, binge drinking - and can lead to numerous negative consequences."

Both Dick and McGue noted the importance of searching for what may lead to adolescent drinking when trying to understand the development of patterns of alcohol use, such as predictors that emerge very early in life.

"That said," noted McGue, "while I think the most important finding concerns tracing personality differences back to preschool differences in temperament, we cannot, from these findings, predict with much accuracy which preschoolers will have problems with alcohol as adolescents and which will not." McGue spoke favorably of unrelated Canadian research that targets personality risk factors for substance abuse; rather than trying to change the personalities of adolescents, scientists are attempting to teach them how to deal with their personalities.

"All things considered," said Dick, "it's not just 'problem kids' who get involved in alcohol use. It's also the highly sociable kids as well. Parents should be aware of this."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our alcohol / addiction / illegal drugs section for the latest news on this subject. Please use one of the following formats to cite this article in your essay, paper or report:

MLA

University, Virginia Commonwealth. "Study Evaluates The Impact Of Childhood Temperament On Later Alcohol Use/Problems." Medical News Today. MediLexicon, Intl., 12 Jul. 2013. Web.
12 Jul. 2013. APA

Please note: If no author information is provided, the source is cited instead.


'Study Evaluates The Impact Of Childhood Temperament On Later Alcohol Use/Problems'

Please note that we publish your name, but we do not publish your email address. It is only used to let you know when your message is published. We do not use it for any other purpose. Please see our privacy policy for more information.

If you write about specific medications or operations, please do not name health care professionals by name.

All opinions are moderated before being included (to stop spam)

Contact Our News Editors

For any corrections of factual information, or to contact the editors please use our feedback form.

Please send any medical news or health news press releases to:

Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.



View the original article here

New Hope In The Fight Against Childhood Cancer

Main Category: Cancer / Oncology
Also Included In: Pediatrics / Children's Health
Article Date: 12 Jul 2013 - 2:00 PDT Current ratings for:
New Hope In The Fight Against Childhood Cancer
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Cancer Research UK scientists at the University of Southampton are seeing positive results in a pre-clinical trial that could bring treatments for a particular aggressive form of childhood cancer closer to reality.

Researchers in the Antibody and Vaccine Group have developed two monoclonal antibodies (mAbs) called anti-4-1BB and anti-CD40 and investigated a third called anti-CTLA-4. Each of these antibodies binds to a different target molecule in the immune system, potentially heightening the body's own immune response to cancer.

Published in the July edition of Clinical Cancer Research, the study has shown that the antibodies boost the immune system to fight neuroblastoma - a form of childhood cancer which grows from undeveloped tissue of the nervous system.

They found that 40 to 60 per cent of the tumours treated with the stimulatory antibodies regressed in the laboratory models and ensured long-term survival. With more aggressive tumours, the antibodies alone did not significantly slow tumour growth, however, when the researchers paired one of the monoclonal antibodies with a cancer vaccine called Survivin a similar survival benefit was seen.

Dr Juliet Gray, Senior Lecturer in Paediatric Oncology and Cancer Research UK scientist at the University of Southampton, comments: "Although this work is still at a pre-clinical stage, we hope it has enabled us to identify a way that we can provide effective immunotherapy treatment against neuroblastoma. More research is needed to understand how these antibodies work and how they should be used to treat neuroblastoma.

"Six out of ten children with neuroblastoma can be successfully treated with conventional chemotherapy. But for those children who don't respond well to this treatment, immunotherapy could become a vital new treatment option."

The body's immune response is generally much weaker to cancer than it is to infections, and in most cases it does not stop tumours from growing. The body holds anti-cancer cells called T-cells, but cancer has the ability to switch off or subdue the immune recognition in these cells.

The antibodies are engineered to wake the T-cells up from their slumber and thereby restore the anti-cancer activity to attack the tumour. This process is already being used in adult trials for a range of cancers including skin, head and neck and pancreatic cancer. This pre-clinical data will allow Dr Gray and her team to design the first peadiatric clinical trials.

Dr Gray, who is also a paediatric oncologist at Southampton General Hospital, adds: "Neuroblastoma affects around 100 children in the UK each year with most cases being diagnosed under the age of five. It is a serious disease but we need to be clear about how to move forward with it. There are a number of things that make conducting a clinical trial in children very challenging. Therefore, it is important that we learn as much as we can in the lab, in advance of a clinical trial, about how this type of therapy can be best used in childhood cancers."

Cancer Research UK scientist, Professor Martin Glennie, Head of the Cancer Sciences at the University of Southampton, who also worked on the study, says: "We very much hope these results will enable us to develop a pioneering immunotherapy treatment for a childhood cancer. In theory this approach enables us to kill cancer cells without damaging healthy cells, resulting in fewer toxic side effects such as hair loss, nausea and tiredness.

"The next stage of our work will be to see if the treatment is a safe and effective treatment for children and also seek to understand how these antibodies can be used in combination with other treatments to maximise their effect."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our cancer / oncology section for the latest news on this subject.

The study was funded by Cancer Research UK, Wessex Cancer Trust, and Wessex Medical Research.

Dr Gray’s paper entitled Immunomodulatory Monoclonal Antibodies Combined with Peptide Vaccination Provide Potent Immunotherapy in an Aggressive Murine Neuroblastoma Model is available to read here

University of Southampton

Please use one of the following formats to cite this article in your essay, paper or report:

MLA

University of Southampton. "New Hope In The Fight Against Childhood Cancer." Medical News Today. MediLexicon, Intl., 12 Jul. 2013. Web.
12 Jul. 2013. APA

Please note: If no author information is provided, the source is cited instead.


'New Hope In The Fight Against Childhood Cancer'

Please note that we publish your name, but we do not publish your email address. It is only used to let you know when your message is published. We do not use it for any other purpose. Please see our privacy policy for more information.

If you write about specific medications or operations, please do not name health care professionals by name.

All opinions are moderated before being included (to stop spam)

Contact Our News Editors

For any corrections of factual information, or to contact the editors please use our feedback form.

Please send any medical news or health news press releases to:

Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.



View the original article here